Systemic autoimmune abnormalities alter the morphology of mucosa-associated lymphoid tissues in the rectum of MRL/MpJ-Fas^lpr/lpr mice.

ABSTRACT: Systemic autoimmune diseases (ADs) might affect the morphology and function of gut-associated lymphoid tissue (LTs) indirectly; however, their exact relationship remains unclear. Therefore, we investigated mouse LTs in the anorectal canal and morphologically compared them between MRL/MpJ-Fas^+/+ and MRL/MpJ-Fas^lpr/lpr mice. LT aggregations, also known as rectal mucosa-associated lymphoid tissues (RMALTs), were exclusively seen in the lamina propria and submucosa of the rectum. The mean size and number of the LT aggregations both significantly increased in MRL/MpJ-Fas^lpr/lpr mice compared to those in MRL/MpJ-Fas^+/+ mice. The distance from the anorectal junction to the first LT aggregate was significantly shorter in MRL/MpJ-Fas^lpr/lpr mic

SUBMITTER: Rubel MZU 

PROVIDER: S-EPMC11254493 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature