Relationship of apolipoprotein C-III proteoform composition with ankle-brachial index and peripheral artery disease in the Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Background and aims

Apolipoprotein C-III (apoC-III) proteoform composition shows distinct relationships with plasma lipids and cardiovascular risk. The present study tested whether apoC-III proteoforms are associated with risk of peripheral artery disease (PAD).

Methods

ApoC-III proteoforms, i.e., native (C-III_0a), and glycosylated with zero (C-III_0b), one (C-III₁) or two (C-III₂) sialic acids, were measured by mass spectrometry immunoassay on 5,734 Multi-Ethnic Study of Atherosclerosis participants who were subsequently followed for clinical PAD over 17 years. Ankle-brachial index (ABI) was also assessed at baseline and then 3 and 10 years later in 4,830 participants.

Results

Higher baseline C-III_0b/C-III_1</

SUBMITTER: Koska J 

PROVIDER: S-EPMC11254547 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature