IL-1R Mediated Activation of Renal Sensory Nerves in DOCA-Salt Hypertension.

ABSTRACT:

Background

Clinical trials of renal denervation for the treatment of hypertension have shown a variety of off-target improvements in conditions associated with sympathetic overactivity. This may be due to the ablation of sympathoexcitatory afferent renal nerves, which are overactive under conditions of renal inflammation. Renal IL (interleukin)-1β is elevated in the deoxycorticosterone acetate-salt model of hypertension, and its activity may be responsible for the elevation in afferent renal nerve activity and arterial pressure.

Methods

Continuous blood pressure recording of deoxycorticosterone acetate-salt mice with IL-1R (IL-1 receptor) knockout or antagonism was used individually and combined with afferent renal denervation (ARDN) to assess mechanistic overlap. Protein qu

SUBMITTER: Baumann D 

PROVIDER: S-EPMC11254549 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature