Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironment.

ABSTRACT:

Background

Accumulating evidence reveals mitochondrial dysfunction exacerbates intestinal barrier dysfunction and inflammation. Despite the growing knowledge of mitochondrial dysfunction and ulcerative colitis (UC), the mechanism of mitochondrial dysfunction in UC remains to be fully explored.

Methods

We integrated 1137 UC colon mucosal samples from 12 multicenter cohorts worldwide to create a normalized compendium. Differentially expressed mitochondria-related genes (DE-MiRGs) in individuals with UC were identified using the "Limma" R package. Unsupervised consensus clustering was utilized to determine the intrinsic subtypes of UC driven by DE-MiRGs. Weighted gene co-expression network analysis was employed to investigate module genes related to UC. Four machine learning al

SUBMITTER: Zhang YF 

PROVIDER: S-EPMC11254623 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature