Plasma proteins and psoriatic arthritis: a proteome-wide Mendelian randomization study.

ABSTRACT:

Background

Previous epidemiological studies have identified a correlation between serum protein levels and Psoriatic Arthritis (PsA). However, the precise nature of this relationship remains uncertain. Therefore, our objective was to assess whether circulating levels of 2,923 plasma proteins are associated with the risk of PsA, utilizing the Mendelian randomization (MR) approach.

Methods

Two-sample MR analysis was performed to assess the causal impact of proteins on PsA risk. Exposure data for plasma proteins were sourced from a genome-wide association study (GWAS) conducted within the UK Biobank Pharma Proteomics Project, which encompassed 2,923 unique plasma proteins. The outcome data for PsA were sourced from the FinnGen study, a large-scale genomics initiative, comprisin

SUBMITTER: Zhao H 

PROVIDER: S-EPMC11254630 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature