The therapeutic and biomarker significance of ferroptosis in chronic myeloid leukemia.

ABSTRACT:

Background

The relationship between ferroptosis and the progression and treatment of hematological tumors has been extensively studied, although its precise association with chronic myeloid leukemia (CML) remains uncertain.

Methods

Multi-transcriptome sequencing data were utilized to analyze the ferroptosis level of CML samples and its correlation with the tumor microenvironment, disease progression, and treatment response. Machine learning algorithms were employed to identify diagnostic ferroptosis-related genes (FRGs). The consensus clustering algorithm was applied to identify ferroptosis-related molecular subtypes. Clinical samples were collected for sequencing to validate the results obtained from bioinformatics analysis. Cell experiments were conducted to investigate th

SUBMITTER: Zhong F 

PROVIDER: S-EPMC11254662 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature