Association between gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study.

ABSTRACT:

Background

To clarify the causal relationship between gut microbiota and diabetic nephropathy (DN), we employed Mendelian randomization (MR). Despite a strong correlation observed, establishing causality is still unclear. By utilizing MR, we aimed to investigate this relationship further and shed light on the potential causal effect of gut microbiota on DN.

Methods

Genetic instrumental variables for gut microbiota were obtained from a GWAS with 18340 participants. DN summary statistics (1032 cases, 451248 controls) were sourced from a separate GWAS. The primary analysis used the inverse-variance weighted (IVW) method. Reverse MR analysis was conducted to explore reverse causation. Rigorous sensitivity analyses were performed to ensure the resilience and reliability of the st

SUBMITTER: Ye Z 

PROVIDER: S-EPMC11254691 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature