Exploring the association between grip strength and adverse pregnancy and perinatal outcomes: A Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have demonstrated an association between grip strength and detrimental pregnancy and perinatal outcomes. However, the causality of this relationship remains uncertain.

Objective

This study aims to investigate if there is a causal relationship between grip strength and adverse pregnancy and perinatal outcomes, providing evidence to support active intervention for adverse pregnancy outcomes.

Study design

A two-sample Mendelian randomization method was used to select GWAS data from the UK Biobank and the FinnGen Biobank as data sources. The inverse variance weighting method was used as the main analysis method. The reliability of the results was verified through sensitivity analysis, including Cochran's Q test, MR-egger intercept

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11254715 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature