Upregulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain.

ABSTRACT: Mitochondria and lysosomes are two organelles that carry out both signaling and metabolic roles in cells. Recent evidence has shown that mitochondria and lysosomes are dependent on one another, as primary defects in one cause secondary defects in the other. Although there are functional impairments in both cases, the signaling consequences of primary mitochondrial dysfunction and lysosomal defects are dissimilar. Here, we used RNA sequencing to obtain transcriptomes from cells with primary mitochondrial or lysosomal defects to identify the global cellular consequences associated with mitochondrial or lysosomal dysfunction. We used these data to determine the pathways affected by defects in both organelles, which revealed a prominent role for the cholesterol synthesis pathway. We observed a

SUBMITTER: Agostini F 

PROVIDER: S-EPMC11254723 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature