Fe₃O₄ coated stent prevent artery neointimal hyperplasia by inhibiting vascular smooth muscle cell proliferation.

ABSTRACT: In-stent restenosis (ISR), caused by aggressive vascular smooth muscle cell (VSMC) proliferation, is a serious complication of stenting. Therefore, developing therapeutic approaches that target VSMC inhibition is imperative. Our previous study showed that VSMC hyperplasia was attenuated after iron stent degradation, and VSMC proliferation around the stented section was arrested. The corrosion products of the iron stents were primarily Fe₃O₄ particles. Therefore, we hypothesized that Fe₃O₄ particles generated by iron stents would prevent neointimal hyperplasia by inhibiting VSMC proliferation. To test this hypothesis, culture assays and flow cytometry were performed to investigate the proliferation of VSMC. Global gene sequencing and Kyoto Encyclo

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11254736 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature