Mechanical release of homogenous proteins from supramolecular gels.

ABSTRACT: A long-standing challenge is how to formulate proteins and vaccines to retain function during storage and transport and to remove the burdens of cold-chain management. Any solution must be practical to use, with the protein being released or applied using clinically relevant triggers. Advanced biologic therapies are distributed cold, using substantial energy, limiting equitable distribution in low-resource countries and placing responsibility on the user for correct storage and handling. Cold-chain management is the best solution at present for protein transport but requires substantial infrastructure and energy. For example, in research laboratories, a single freezer at -80 °C consumes as much energy per day as a small household¹. Of biological (protein or cell) therapies and a

SUBMITTER: Bianco S 

PROVIDER: S-EPMC11254749 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature