Unraveling the relationship between gut microbiota and site-specific endometriosis: a Mendelian randomization analysis.

ABSTRACT:

Background

Although numerous studies have illustrated the connection between gut microbiota and endometriosis, a conspicuous gap exists in research focusing on the pathogenesis of endometriosis at various sites and its linkage with infertility.

Methods

In this study, we used a two-sample Mendelian randomization analysis to investigate the effect of gut microbiota on the development of endometriosis in different regions, including the uterus, ovary, fallopian tube, pelvic peritoneum, vagina, and rectovaginal septum, as well as the intestine. Additionally, we explored the correlation between gut microbiota and endometriosis-induced infertility. Genetic associations with gut microbes were obtained from genome-wide association study (GWAS) datasets provided by the MiBioGen conso

SUBMITTER: Tang Y 

PROVIDER: S-EPMC11254793 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature