Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach.

ABSTRACT:

Background

The ongoing global health crisis of COVID-19, and particularly the challenges posed by recurrent infections of the Omicron variant, have significantly strained healthcare systems worldwide. There is a growing body of evidence indicating an increased susceptibility to Omicron infection in patients suffering from Acute Kidney Injury (AKI). However, the intricate molecular interplay between AKI and Omicron variant of COVID-19 remains largely enigmatic.

Methods

This study employed a comprehensive analysis of human RNA sequencing (RNA-seq) and microarray datasets to identify differentially expressed genes (DEGs) associated with Omicron infection in the context of AKI. We engaged in functional enrichment assessments, an examination of Protein-Protein Interaction (PPI) n

SUBMITTER: Wang L 

PROVIDER: S-EPMC11254815 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature