Osteostaticytes: A novel osteoclast subset couples bone resorption and bone formation.

ABSTRACT:

Background

Osteomyelitis (OM) is an inflammatory condition of bone characterized by cortical bone devascularization and necrosis. Dysregulation of bone remodelling is triggered by OM. Bone remodelling is precisely coordinated by bone resorption and formation via a reversal phase. However, the cellular and molecular mechanisms underlying bone remodelling failure after osteomyelitis remain elusive.

Methods

To elucidate the cellular and molecular mechanism underlying bone healing after osteomyelitis, we employed single-cell RNA sequencing (scRNA-seq) to depict the atlas of human cortical bone in normal, infected and reconstructed states. Dimensionality reduction by t-stochastic neighbourhood embedding (t-SNE) and graph-based clustering were applied to analyse the detailed clust

SUBMITTER: Wei Z 

PROVIDER: S-EPMC11254843 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature