Absence of association between maternal adverse events and long-term gut microbiome outcomes in the Australian autism biobank.

ABSTRACT:

Introduction

Maternal immune activation (MIA) and prenatal maternal stress (MatS) are well-studied risk factors for psychiatric conditions such as autism and schizophrenia. Animal studies have proposed the gut microbiome as a mechanism underlying this association and have found that risk factor-related gut microbiome alterations persist in the adult offspring. In this cross-sectional study, we assessed whether maternal immune activation and prenatal maternal stress were associated with long-term gut microbiome alterations in children using shotgun metagenomics.

Methods

This cross-sectional study included children diagnosed with autism (N = 92), siblings without a diagnosis (N = 42), and unrelated children (N = 40) without a diagnosis who were recruited into the Australian Au

SUBMITTER: Vasileva S 

PROVIDER: S-EPMC11254947 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature