METTL14 promotes lipid metabolism reprogramming and sustains nasopharyngeal carcinoma progression via enhancing m⁶A modification of ANKRD22 mRNA.

ABSTRACT:

Background

N⁶-methyladenosine (m⁶A) modification is essential for modulating RNA processing as well as expression, particularly in the context of malignant tumour progression. However, the exploration of m⁶A modification in nasopharyngeal carcinoma (NPC) remains very limited.

Methods

RNA m⁶A levels were analysed in NPC using m⁶A dot blot assay. The expression level of methyltransferase-like 14 (METTL14) within NPC tissues was analysed from public databases as well as RT-qPCR and immunohistochemistry. The influences on METTL14 expression on NPC proliferation and metastasis were explored via in vitro as well as in vivo functional assays. Targeted genes of METTL14 were screened using the m⁶A and gene expression p

SUBMITTER: Li L 

PROVIDER: S-EPMC11255023 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature