Hidradenitis suppurativa and cardiovascular diseases: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Prior investigation has indicated a link between Hidradenitis suppurativa (HS) and cardiovascular diseases (CVDs), yet the causal relationship (CR) between these conditions remains unresolved.

Methods

This investigation utilized bidirectional Mendelian randomization (MR) analysis to determine the CR between HS and CVDs. Genetic instruments for both conditions were sourced from genome-wide association studies (GWAS). The GWAS summary data for CVD comprised coronary artery disease (CAD), myocardial infarction (MI), coronary atherosclerosis (CA), ischemic stroke (IS), and chronic heart failure (CHF). Four new approaches were added to the inverse variance weighted (IVW) method for the main analysis: weighted median, weighted MR-Egger, simple mode, and weighted mode. T

SUBMITTER: Zhou P 

PROVIDER: S-EPMC11255035 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature