Individual Differences in Volitional Social Self-Administration and Motivation in Male and Female Mice Following Social Stress.

ABSTRACT:

Background

A key challenge in developing treatments for neuropsychiatric illness is the disconnect between preclinical models and the complexity of human social behavior. We integrate voluntary social self-administration into a rodent model of social stress as a platform for the identification of fundamental brain and behavior mechanisms underlying stress-induced individual differences in social motivation.

Methods

Here, we introduced an operant social stress procedure in male and female mice composed of 3 phases: 1) social self-administration training, 2) social stress exposure concurrent with reinforced self-administration testing, and 3) poststress operant testing under nonreinforced and reinforced conditions. We used social-defeat and witness-defeat stress in male and fe

SUBMITTER: Navarrete J 

PROVIDER: S-EPMC11255129 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature