Organ and tumor dosimetry including method simplification for [¹⁷⁷Lu]Lu-PSMA-I&T for treatment of metastatic castration resistant prostate cancer.

ABSTRACT:

Background

Internal dosimetry in individual patients is essential for safe and effective radioligand therapy. Multiple time point imaging for accurate dosimetry is time consuming and hence can be demanding for nuclear medicine departments as well as patients. The objectives of this study were (1) to assess absorbed doses to organs at risk and tumor lesions for [¹⁷⁷Lu]Lu-PSMA-I&T using whole body SPECT imaging and (2) to investigate possible simplified dosimetry protocols.

Methods

This study included 16 patients each treated with 4 cycles of [¹⁷⁷Lu]Lu-PSMA-I&T. They underwent quantitative whole body SPECT/CT imaging (3 bed positions) at four time points (TP) comprising 2 h, 24 h, 48 h and 72-168 h post-injection (p.i.). Full 3D dosimetry (reference metho

SUBMITTER: Karimzadeh A 

PROVIDER: S-EPMC11255161 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature