Trophoblast Cell Surface Antigen 2 Expression in Thymic Carcinoma: Brief Report.

ABSTRACT:

Introduction

Trophoblast cell surface antigen 2 (TROP2) is a transmembrane glycoprotein overexpressed in various cancer types. Although TROP2-targeting therapy is currently attracting attention, little is known about TROP2 expression in thymic carcinoma.

Methods

TROP2 gene expression in thymic epithelial tumors was analyzed using RNA-sequencing (RNA-seq) data for 122 cases obtained from The Cancer Genome Atlas. Immunohistochemistry (IHC) staining with anti-TROP2 antibody (SP295) was performed in 26 cases of thymic carcinoma tissues surgically resected at Juntendo University.

Results

RNA-seq data analysis from The Cancer Genome Atlas revealed that TACSTD2 (gene encoding TROP2) expression was significantly higher in thymic carcinoma than in thymoma (adjusted p

SUBMITTER: Kurokawa K 

PROVIDER: S-EPMC11255346 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature