Identification and experimental validation of m7G-related molecular subtypes, immune signature, and feature genes in Alzheimer's disease.

ABSTRACT:

Background

Studies has shown that N7-methylguanosine (m7G) modification plays a critical role in neurological diseases. However, the exact role and association of m7G with the immune microenvironment in Alzheimer's disease (AD) remain largely unknown and unexplored.

Methods

The study datasets comprised 667 AD samples and 503 control samples selected from eight datasets in the Gene Expression Omnibus database; m7G regulator genes were obtained from previous literature. The AD subtypes were identified by consensus clustering analysis according to m7G regulator genes. The clinical characteristics, immune infiltration, and biological functions of the AD subgroups were evaluated. A combination of different types of machine-learning algorithms were used for the identification of A

SUBMITTER: Lian P 

PROVIDER: S-EPMC11255592 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature