Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2.

ABSTRACT:

Background

Dihydroartemisinin (DHA), a derivative of Artemisia annua, has been shown to possess anti-inflammatory properties. Besides, Yes-associated protein 1 (YAP1) plays a crucial role in maintaining liver homeostasis.

Methods

This study used Yap1 ^Flox/Flox, Albumin-Cre mice with hepatocyte-specific Yap1 knockout (referred to as Yap1 ^LKO) and their control mice (Yap1 ^Flox/Flox, referred to as Yap1 ^Flox). The effect of Yap1 on lipid metabolism homeostasis was investigated through non-targeted metabolomic analysis of mouse liver. Subsequently, DHA was administered to Yap1 ^LKO mice to assess its potential as a treatment. Liver pathology was evaluated via H&E staining, and

SUBMITTER: Xue Y 

PROVIDER: S-EPMC11255665 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature