Cendakimab in Patients With Moderate to Severe Atopic Dermatitis: A Randomized Clinical Trial.

ABSTRACT:

Importance

Cendakimab selectively targets interleukin (IL)-13, a type 2 cytokine implicated in atopic dermatitis (AD) pathogenesis, by inhibiting binding to its receptors (IL13R-α1 and IL13R-α2). Proof-of-concept work in AD supports using cendakimab for type 2 inflammatory diseases.

Objective

To evaluate the efficacy and safety of cendakimab compared with placebo in patients with moderate to severe AD.

Design, setting, and participants

This phase 2, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging clinical trial was conducted from May 2021 to November 2022. Adult patients with moderate to severe AD and inadequate response to topical medications were enrolled at 69 sites in 5 countries (US [n = 26], Japan [n = 17], Canada [n = 9], Poland [n = 

SUBMITTER: Blauvelt A 

PROVIDER: S-EPMC11255973 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature