Statin prescriptions and progression of advanced fibrosis risk in primary care patients with MASLD.

ABSTRACT:

Objective

We aimed to determine the association of statins with progression to a high risk for advanced fibrosis in primary care patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Design

This retrospective cohort study of electronic health record data included patients with MASLD and an initial low or indeterminate risk for advanced fibrosis, determined by Fibrosis-4 Index (FIB-4) score (<2.67). Patients were followed from the index FIB-4 until the primary outcome of a high-risk FIB-4 (≥2.67) or the end of the study period. Prescription for a statin during follow-up was the primary exposure. We developed Cox regression models for the time to a high-risk FIB-4 score with statin therapy as the primary covariate and adjusting for baseline fibrosis r

SUBMITTER: Schreiner AD 

PROVIDER: S-EPMC11256061 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature