Causal impact of human blood metabolites and metabolic pathways on serum uric acid and gout: a mendelian randomization study.

ABSTRACT:

Objective

Hyperuricaemia and gout are common metabolic disorders. However, the causal relationships between blood metabolites and serum urate levels, as well as gout, remain unclear. A systematic evaluation of the causal connections between blood metabolites, hyperuricemia, and gout could enhance early screening and prevention of hyperuricemia and gout in clinical settings, providing novel insights and approaches for clinical treatment.

Methods

In this study, we employed a bidirectional two-sample Mendelian randomization analysis utilizing data from a genome-wide association study involving 7,286 participants, encompassing 486 blood metabolites. Serum urate and gout data were sourced from the Chronic Kidney Disease Genetics consortium, including 288,649 participants for seru

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC11256090 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature