Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum.

ABSTRACT: There is limited information about the impact of Zika virus (ZIKV) exposure in utero on the anti-ZIKV immune responses of offspring. We infected six rhesus macaque dams with ZIKV early or late in pregnancy and studied four of their offspring over the course of a year postpartum. Despite evidence of ZIKV exposure in utero, we observed no structural brain abnormalities in the offspring. We detected infant-derived ZIKV-specific immunoglobulin A antibody responses and T cell memory responses during the first year postpartum in the two offspring born to dams infected with ZIKV early in pregnancy. Critically, although the infants had acquired some immunological memory of ZIKV, it was not sufficient to protect them against reinfection with ZIKV at 1 year postpartum. The four offspring reexposed t

SUBMITTER: Vannella KM 

PROVIDER: S-EPMC11256112 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature