Chronic cannabis use alters the spontaneous and oscillatory gamma dynamics serving cognitive control.

ABSTRACT: Regular cannabis use is associated with cortex-wide changes in spontaneous and oscillatory activity, although the functional significance of such changes remains unclear. We hypothesized that regular cannabis use would suppress spontaneous gamma activity in regions serving cognitive control and scale with task performance. Participants (34 cannabis users, 33 nonusers) underwent an interview regarding their substance use history and completed the Eriksen flanker task during magnetoencephalography (MEG). MEG data were imaged in the time-frequency domain and virtual sensors were extracted from the peak voxels of the grand-averaged oscillatory interference maps to quantify spontaneous gamma activity during the pre-stimulus baseline period. We then assessed group-level differences in spontaneou

SUBMITTER: Schantell M 

PROVIDER: S-EPMC11256138 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature