Effect of recombinant human thyroid stimulating hormone on radioactive iodine uptake by thyroid carcinoma in dogs.

ABSTRACT:

Background

The high doses of radioiodine-131 (¹³¹I) and, subsequently, the high radioactive burden for dog and environment warrants optimization of ¹³¹I therapy in dogs with thyroid carcinoma (TC).

Hypothesis/objectives

To evaluate the effect of a revised protocol with recombinant human thyroid stimulating hormone (rhTSH) on tumor radioactive iodine uptake (RAIU) in dogs with TC.

Animals

Nine client-owned dogs diagnosed with TC.

Methods

A prospective cross-over study in which tumor RAIU was calculated and compared at 8 hours (8h-RAIU) and 24 hours (24h-RAIU) after injection of radioactive iodine-123 (¹²³I), once with and once without rhTSH (ie, 250 μg, IM, 24 and 12 hours before ¹²³I) in each dog. Simultaneously, seru

SUBMITTER: Scheemaeker S 

PROVIDER: S-EPMC11256155 | biostudies-literature | 2024 Jul-Aug

REPOSITORIES: biostudies-literature