Genetic association and functional implications of TLR4 rs1927914 polymorphism on colon cancer risk.

ABSTRACT:

Background

Colon cancer remains a major health concern worldwide, with genetic factors playing a crucial role in its development. Toll-like receptors (TLRs) has been implicated in various cancers, but their role in colon cancer is not well understood. This study aims to identify functional polymorphisms in the promoter and 3'UTR regions of TLRs and evaluate their association with colon cancer susceptibility.

Methods

We conducted a case-control study involving 410 colon cancer patients and 410 healthy controls from the Chinese population. Genotyping of polymorphisms in TLR3, TLR4, TLR5 and TLR7 was performed using PCR-RFLP and TaqMan MGB probes. Using logistic regression analysis, we evaluated the association of TLRs polymorphisms and the susceptibility to colon cancer. To un

SUBMITTER: Li A 

PROVIDER: S-EPMC11256370 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature