Gut microbes on the risk of advanced adenomas.

ABSTRACT:

Background

More than 90% of colorectal cancer (CRC) arises from advanced adenomas (AA) and gut microbes are closely associated with the initiation and progression of both AA and CRC.

Objective

To analyze the characteristic microbes in AA.

Methods

Fecal samples were collected from 92 AA and 184 negative control (NC). Illumina HiSeq X sequencing platform was used for high-throughput sequencing of microbial populations. The sequencing results were annotated and compared with NCBI RefSeq database to find the microbial characteristics of AA. R-vegan package was used to analyze α diversity and β diversity. α diversity included box diagram, and β diversity included Principal Component Analysis (PCA), principal co-ordinates analysis (PCoA), and non-metric multidimensional sca

SUBMITTER: Jing Z 

PROVIDER: S-EPMC11256391 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature