Cholinergic nucleus degeneration and its association with gait impairment in Parkinson's disease.

ABSTRACT:

Background

The contribution of cholinergic degeneration to gait disturbance in Parkinson's disease (PD) is increasingly recognized, yet its relationship with dopaminergic-resistant gait parameters has been poorly investigated. We investigated the association between comprehensive gait parameters and cholinergic nucleus degeneration in PD.

Methods

This cross-sectional study enrolled 84 PD patients and 69 controls. All subjects underwent brain structural magnetic resonance imaging to assess the gray matter density (GMD) and volume (GMV) of the cholinergic nuclei (Ch123/Ch4). Gait parameters under single-task (ST) and dual-task (DT) walking tests were acquired using sensor wearables in PD group. We compared cholinergic nucleus morphology and gait performance between groups and

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11256459 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature