Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury.

ABSTRACT:

Background

The discovery of new prognostic biomarkers following spinal cord injury (SCI) is a rapidly growing field that could help uncover the underlying pathological mechanisms of SCI and aid in the development of new therapies. To date, this search has largely focused on the initial days after the lesion. However, during the subacute stage of SCI (weeks to months after the injury), there remains potential for sensorimotor recovery, and numerous secondary events develop in various organs. Additionally, the confounding effects of early interventions after the injury are less likely to interfere with the results.

Methods

In this study, we conducted an untargeted proteomics analysis to identify biomarkers of recovery in blood serum samples during the subacute phase of SCI pat

SUBMITTER: Garcia-Ovejero D 

PROVIDER: S-EPMC11256486 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature