IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.

ABSTRACT:

Background

Z-DNA binding protein 1 (ZBP1) is a nucleic acid sensor that is involved in multiple inflammatory diseases, but whether and how it contributes to osteoarthritis (OA) are unclear.

Methods

Cartilage tissues were harvested from patients with OA and a murine model of OA to evaluate ZBP1 expression. Subsequently, the functional role and mechanism of ZBP1 were examined in primary chondrocytes, and the role of ZBP1 in OA was explored in mouse models.

Results

We showed the upregulation of ZBP1 in articular cartilage originating from OA patients and mice with OA after destabilization of the medial meniscus (DMM) surgery. Specifically, knockdown of ZBP1 alleviated chondrocyte damage and protected mice from DMM-induced OA. Mechanistically, tumor necrosis factor alpha

SUBMITTER: Sun K 

PROVIDER: S-EPMC11256489 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature