Discovery of crucial cytokines associated with deep vein thrombus formation by protein array analysis.

ABSTRACT:

Background

Expanding the number of biomarkers is imperative for studying the etiology and improving venous thromboembolism prediction. In this study, we aimed to identify promising biomarkers or targeted therapies to improve the detection accuracy of early-stage deep vein thrombosis (DVT) or reduce complications.

Methods

Quantibody Human Cytokine Antibody Array 440 (QAH-CAA-440) was used to screen novel serum-based biomarkers for DVT/non-lower extremity DVT (NDVT). Differentially expressed proteins in DVT were analyzed using bioinformatics methods and validated using a customized array. Diagnostic accuracy was calculated using receiver operating characteristics, and machine learning was applied to establish a biomarker model for evaluating the identified targets. Twelve targ

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11256513 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature