Pediatric antibody responses to SARS-CoV-2 after infection and vaccination in Calgary, Canada.

ABSTRACT:

Background

There are few reports of longitudinal serologic responses in children following Sars-CoV-2 infection and vaccination. This study describes longitudinal SARS-CoV-2 antibody responses following infection, vaccination, or both (hybrid immunity) in a cohort of Canadian children. The objectives of our study were to compare antibody levels following SARS-CoV-2 infection, vaccination, and hybrid immunity and to examine antibody decline after final antigen exposure.

Methods

The Alberta Childhood COVID-19 Cohort (AB3C) study was a prospective longitudinal cohort study conducted from July 2020 to September 2022 with repeat sampling across 5 visits. Children under 18 years of age were enrolled for serial measurement of antibody responses to SARS-CoV-2 virus vaccine and infec

SUBMITTER: Ricketson LJ 

PROVIDER: S-EPMC11256562 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature