Evolution and genotypic characteristics of small cell lung cancer transformation in non-small cell lung carcinomas.

ABSTRACT:

Background

Small cell lung cancer (SCLC) transformation had previously been reported mainly in epidermal growth factor receptor (EGFR) mutant adenocarcinoma. However, the underlying genomic profile remains unclear. Our study aimed to find the evolution and genotypic characteristic of SCLC transformation.

Methods

Thirty-one SCLC transformation patients who were initially diagnosed as non-small cell lung cancer (NSCLC) patients were included. Whole exome sequencing (WES) of both primary and transformed re-biopsy lesions was conducted on 12 patients. Clinical characteristics were analyzed using R software (v.3.6.1).

Results

Our study included 31 patients, of whom, three had lung squamous cell carcinoma, 6 patients did not carry EGFR mutations, and 30 patients received ch

SUBMITTER: Zhong J 

PROVIDER: S-EPMC11256618 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature