The associations between dysregulation of human blood metabolites and lung cancer risk: evidence from genetic data.

ABSTRACT:

Background

Metabolic dysregulation is recognized as a significant hallmark of cancer progression. Although numerous studies have linked specific metabolic pathways to cancer incidence, the causal relationship between blood metabolites and lung cancer risk remains unclear.

Methods

Genomic data from 29,266 lung cancer patients and 56,450 control individuals from the Transdisciplinary Research in Cancer of the Lung and the International Lung Cancer Consortium (TRICL-ILCCO) were utilized, and findings were replicated using additional data from the FinnGen consortium. The analysis focused on the associations between 486 blood metabolites and the susceptibility to overall lung cancer and its three major clinical subtypes. Various Mendelian randomization methods, including inverse-

SUBMITTER: Wu G 

PROVIDER: S-EPMC11256634 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature