Effects of walking on epigenetic age acceleration: a Mendelian randomization study.

ABSTRACT:

Introduction

Walking stands as the most prevalent physical activity in the daily lives of individuals and is closely associated with physical functioning and the aging process. Nonetheless, the precise cause-and-effect connection between walking and aging remains unexplored. The epigenetic clock emerges as the most promising biological indicator of aging, capable of mirroring the biological age of the human body and facilitating an investigation into the association between walking and aging. Our primary objective is to investigate the causal impact of walking with epigenetic age acceleration (EAA).

Methods

We conducted a two-sample two-way Mendelian randomization (MR) study to investigate the causal relationship between walking and EAA. Walking and Leisure sedentary behavio

SUBMITTER: Chen GY 

PROVIDER: S-EPMC11256679 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature