Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer.

ABSTRACT:

Purpose

This study aimed to examine the effect of radiation esophagitis (RE) and the dynamics of RE on subsequent survival in non-small cell lung cancer (NSCLC) patients who underwent radiotherapy.

Experimental design

Patients with NSCLC treated with fractionated thoracic radiotherapy enrolled in prospective trials were eligible. RE was graded prospectively according to Common Terminology Criteria for Adverse Events (CTCAE) v3.0 per protocol requirement weekly during-RT and 1 month after RT. This study applied conditional survival assessment which has advantage over traditional survival analysis as it assesses the survival from the event instead of from the baseline. P-value less than 0.05 was considered to be significant. The primary endpoint is overall survival.

SUBMITTER: Yu H 

PROVIDER: S-EPMC11256695 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature