Benefits and harms of screening for hepatocellular carcinoma in high-risk populations: systematic review and meta-analysis.

ABSTRACT:

Objective

The incidence and mortality of hepatocellular carcinoma (HCC) have been increasing around the world. Current guidelines recommend HCC screening in high-risk population. However, the strength of evidence of benefits and harms of HCC screening to support the recommendation was unclear. The objective is to systematically synthesize current evidence on the benefits and harms of HCC screening.

Methods

We searched PubMed and nine other databases until August 20, 2021. We included cohort studies and RCTs that compared the benefits and harms of screening and non-screening in high-risk population of HCC. Case series studies that reported harms of HCC screening were also included. Pooled risk ratio (RR), according to HCC screening status, was calculated for each benefit outc

SUBMITTER: Yang J 

PROVIDER: S-EPMC11256723 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature