The unique genomic landscape and prognostic mutational signature of Chinese clear cell renal cell carcinoma.

ABSTRACT:

Background

The genomic background affects the occurrence and metastasis of cancers, including clear cell renal cell carcinoma (ccRCC). However, reports focusing on the prognostic mutational signature of Chinese ccRCC are lacking.

Methods

Overall, 929 patients, including a training cohort with Chinese patients (n = 201), a testing cohort with Caucasian patients (n = 274), and a validation cohort (n = 454) were analyzed for the genomic landscape of ccRCC. Then, machine-learning algorithms were used to identify and evaluate the genomic mutational signature (GMS) in ccRCC. Analyses for prognosis, immune microenvironment, association with independent clinicopathological features, and predictive responses for immune checkpoint therapies (ICTs) were performed.<

SUBMITTER: Xu W 

PROVIDER: S-EPMC11256728 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature