Identification of key genes associated with acute myocardial infarction using WGCNA and two-sample mendelian randomization study.

ABSTRACT:

Objective

Acute myocardial infarction (AMI) is a severe condition with high morbidity and mortality rates. This study aimed to identify hub genes potentially associated with AMI and assess their clinical utility in predicting AMI occurrence.

Methods

Gene microarray data were obtained from the Gene Expression Omnibus (GEO) database. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were conducted on samples from patients with AMI and control samples to identify modules significantly associated with AMI. GO and KEGG analyses were applied to investigate the potential functions of these hub genes. Lastly, the mendelian randomization (MR) method was applied to analyze the causal relationship between the hub gene TNF and AMI.

Results

SUBMITTER: Yang X 

PROVIDER: S-EPMC11257238 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature