Trans-ancestry analysis in over 799,000 individuals yields new insights into the genetic etiology of colorectal cancer.

ABSTRACT:

Background

Recent studies have demonstrated the relevance of circulating factors in the occurrence and development of colorectal cancer (CRC); however, the causal relationship remains unclear.

Methods

Summary-level data for CRC were obtained from the UK Biobank (5,657 cases and 372,016 controls), FinnGen cohort (3,022 cases and 215,770 controls), and BioBank Japan Project (BBJ, 7,062 cases and 195,745 controls). Thirty-two peripheral markers with consistent definitions were collected from the three biobanks. Mendelian randomization (MR) was used to evaluate the causal effect of circulating factors on CRC. The effects from the three consortiums were combined using trans-ancestry meta-analysis methods.

Results

Our analysis provided compelling evidence for the causal ass

SUBMITTER: Yang C 

PROVIDER: S-EPMC11257326 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature