Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed.

ABSTRACT: Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments (e.g., all-optical interrogation, closed-loop control) for interrogating neural circuits. Unfortunately, these advances have drastically increased the complexity of designing experiments, with ad hoc decisions often resulting in suboptimal or even failed experiments. Bridging model and experiment via simulation can help solve this problem, leveraging advances in computational models to provide a low-cost testbed for experiment design, model validation, and methods engineering. Specifically, we require an integrated approach that incorporates simulation of the experimental interface into computational models, but no existing tool integrates optogenetics,

SUBMITTER: Johnsen KA 

PROVIDER: S-EPMC11257437 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature