Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance.

ABSTRACT: The ability to calibrate learning according to new information is a fundamental component of an organism's ability to adapt to changing conditions. Yet, the exact neural mechanisms guiding dynamic learning rate adjustments remain unclear. Catecholamines appear to play a critical role in adjusting the degree to which we use new information over time, but individuals vary widely in the manner in which they adjust to changes. Here, we studied the effects of a low dose of methamphetamine (MA), and individual differences in these effects, on probabilistic reversal learning dynamics in a within-subject, double-blind, randomized design. Participants first completed a reversal learning task during a drug-free baseline session to provide a measure of baseline performance. Then they completed the ta

SUBMITTER: Kirschner H 

PROVIDER: S-EPMC11257491 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature