Loss of <i>cped1</i> does not affect bone and lean tissue in zebrafish.

ABSTRACT: Human genetic studies have nominated Cadherin-like and PC-esterase Domain-containing 1 (CPED1) as a candidate target gene mediating bone mineral density (BMD) and fracture risk heritability. Recent efforts to define the role of CPED1 in bone in mouse and human models have revealed complex alternative splicing and inconsistent results arising from gene targeting, making its function in bone difficult to interpret. To better understand the role of CPED1 in adult bone mass and morphology, we conducted a comprehensive genetic and phenotypic analysis of cped1 in zebrafish, an emerging model for bone and mineral research. We analyzed two different cped1 mutant lines and performed deep phenotyping to characterize more than 200 measures of adult vertebral, cranio

SUBMITTER: Alvarado K 

PROVIDER: S-EPMC11257572 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature