Neuronal GPCR NMUR-1 regulates energy homeostasis in response to pathogen infection.

ABSTRACT: A key question in current immunology is how the innate immune system generates high levels of specificity. Our previous study in Caenorhabditis elegans revealed that NMUR-1, a neuronal G protein-coupled receptor homologous to mammalian receptors for the neuropeptide neuromedin U (NMU), regulates distinct innate immune responses to different bacterial pathogens. Here, by using quantitative proteomics and functional assays, we discovered that NMUR-1 regulates F₁F_O ATP synthase and ATP production in response to pathogen infection, and that such regulation contributes to NMUR-1-mediated specificity of innate immunity. We further demonstrated that ATP biosynthesis and its contribution to defense is neurally controlled by the NMUR-1 ligand CAPA-1 and its expressing n

SUBMITTER: Wibisono P 

PROVIDER: S-EPMC11257582 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature