Functional ultrasound imaging and neuronal activity: how accurate is the spatiotemporal match?

ABSTRACT: Over the last decade, functional ultrasound (fUS) has risen as a critical tool in functional neuroimaging, leveraging hemodynamic changes to infer neural activity indirectly. Recent studies have established a strong correlation between neural spike rates (SR) and functional ultrasound signals. However, understanding their spatial distribution and variability across different brain areas is required to thoroughly interpret fUS signals. In this regard, we conducted simultaneous fUS imaging and Neuropixels recordings during stimulus-evoked activity in awake mice within three regions the visual pathway. Our findings indicate that the temporal dynamics of fUS and SR signals are linearly correlated, though the correlation coefficients vary among visual regions. Conversely, the spatial correlatio

SUBMITTER: Lambert T 

PROVIDER: S-EPMC11257620 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature