Selective consolidation of learning and memory via recall-gated plasticity.

ABSTRACT: In a variety of species and behavioral contexts, learning and memory formation recruits two neural systems, with initial plasticity in one system being consolidated into the other over time. Moreover, consolidation is known to be selective; that is, some experiences are more likely to be consolidated into long-term memory than others. Here, we propose and analyze a model that captures common computational principles underlying such phenomena. The key component of this model is a mechanism by which a long-term learning and memory system prioritizes the storage of synaptic changes that are consistent with prior updates to the short-term system. This mechanism, which we refer to as recall-gated consolidation, has the effect of shielding long-term memory from spurious synaptic changes, enablin

SUBMITTER: Lindsey JW 

PROVIDER: S-EPMC11257680 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature