Cardiovascular Mortality and Duration of Androgen Deprivation in Locally Advanced Prostate Cancer: Long-term Update of NRG/RTOG 9202.

ABSTRACT:

Background

Androgen deprivation therapy (ADT) has been associated with coronary heart disease and myocardial infarction (MI) in prostate cancer patients, but controversy persists regarding its effects on cardiovascular mortality (CVM).

Objective

We assessed the long-term relationship between ADT and CVM in a prostate cancer randomized trial (NRG Oncology/Radiation Therapy Oncology Group 9202).

Design, setting, and participants

From 1992 to 1995, 1554 men with locally advanced prostate cancer (T2c-T4, prostate-specific antigen <150 ng/ml) received radiotherapy with 4 mo (short-term [STADT]) versus 28 mo (longer-term [LTADT]) of ADT.

Outcome measurements and statistical analysis

Using the Fine-Gray and Cox regression models, the relationship between ADT and morta

SUBMITTER: Mak KS 

PROVIDER: S-EPMC11257781 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature